Non-treatment-related chronic myeloid leukemia as a second malignancy

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• 作者：Specchia ; Giorgina ; Buquicchio ; Caterina ; Albano ; Francesco ; Liso ; Arcangelo ; Pannunzio ; Alessandra ; et. al.
• 关键词：nTr-CML ; non-treatment-related chronic myeloid leukemia ; Tr-CML ; treatment-related chronic myeloid leukemia ; RT ; radiotherapy ; CHT ; chemotherapy ; CLL ; chronic lymphocytic leukemia ; HCL ; hairy cell leukemia ; Chronic myeloid leukemia ; Second malignancy ; Non
• 刊名：Leukemia Research
• 出版年：2004
• 出版时间：February, 2004
• 年：2004
• 卷：28
• 期：2
• 页码：115-119
• 全文大小：83.5 K

文摘

The characteristics of the very rare non-treatment-related chronic myeloid leukemia (nTr-CML) cases have never before been analyzed. The literature up to December 2002 was screened using the Medline database to identify cases of Tr-CML and nTr-CML. We considered five cases with nTr-CML identified among 270 newly diagnosed CML at our Department. Our report thus considers nine cases with nTr-CML compared to 77 affected by Tr-CML as a secondary neoplasm. The median age at the appearance of the first tumor was higher in nTr-CML patients compared to that of the Tr-CML group (P<0.0001). The median age at CML diagnosis was significantly higher in the nTr-CML than in the Tr-CML group (P<0.0001). The proportion of hematological malignancies as first tumor type was not different in the two groups (44 % in nTr-CML versus 56 % in Tr-CML). Our study underlines that nTr-CML as a second malignancy is a rare entity associated with elderly age.