A Comprehensive Assessment of Toxicities in Patients with Central Nervous System Lymphoma Undergoing Autologous Stem Cell Transplantation Using Thiotepa, Busulfan, and Cyclophosphamide Conditioning

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• 作者：Michael Scordo¹ ; ^{scordom@mskcc.org} ; Valkal Bhatt¹ ; Meier Hsu² ; Antonio M. Omuro³ ; ⁴ ; Matthew J. Matasar⁵ ; ⁶ ; Lisa M. DeAngelis³ ; ⁴ ; Parastoo B. Dahi¹ ; ⁶ ; Craig H. Moskowitz⁵ ; ⁶ ; Sergio A. Giralt¹ ; ⁶ ; Craig S. Sauter¹ ; ⁶
• 关键词：High-dose therapy ; Autologous stem cell transplantation ; Central nervous system lymphoma ; Toxicity ; Regimen-related toxicity
• 刊名：Biology of Blood and Marrow Transplantation
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：23
• 期：1
• 页码：38-43
• 全文大小：642 K
• 卷排序：23

文摘

Although effective, TBC-conditioned ASCT for CNSL is associated with suboptimal TRM. Patient characteristics and busulfan AUC levels did not correlate with increased toxicity. We identified excessive mucosal toxicity, which will be targeted in future studies.