Neurotrophic and neuroprotective effects of oxyntomodulin in neuronal cells and a rat model of stroke

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• 作者：Yazhou Li^a ; ^{liyaz@mail.nih.gov} ; Kou-Jen Wu^b ; Seong-Jin Yu^b ; Ian A. Tamargo^a ; Yun Wang^b ; Nigel H. Greig^a ; ^{greign@mail.nih.gov}
• 关键词：Oxyntomodulin ; Neuroprotection ; Stroke ; Glucagon-like peptide-1 receptor ; Glucagon receptor ; Glutamate excitotoxicity ; Oxidative stress
• 刊名：Experimental Neurology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：288
• 期：Complete
• 页码：104-113
• 全文大小：1338 K
• 卷排序：288

文摘

We evaluated the neurotrophic and neuroprotective actions of OXM in neuronal cultures and in an ischemic stroke model. OXM provided neurotrophic properties in immortal human SH-SY5Y neuronal cells - elevating cAMP levels and pCREB. OXM provided neuroprotection against glutamate excitotoxicity and oxidative stress injury in SH-SY5Y cells and rat primary neurons. OXM actions were primarily mediated by the GLP-1R but not GCGR, and involved the PKA and MAPK but not PI3K pathway. OXM significantly reduced cerebral infarct size and improved locomotor activities in a transient MCAo rat model of stroke.