The triterpene echinocystic acid and its 3-O-glucoside derivative are revealed as potent and selective glucocorticoid receptor agonists
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文摘

Prediction of glucocorticoid receptor-echinocytic acids binding via molecular docking.

Echinocystic acids induce glucocorticoid receptor nuclear translocation.

Echinocystic acids induce NFκΒ transrepression via glucocorticoid receptor activation.

Echinocystic acids act as potent dissociated glucocorticoid receptor ligands.

Echinocystic acids augment DEX-induced mitochondrial dependent apoptosis.

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