Interferon-alpha-induced inflammation is associated with reduced glucocorticoid negative feedback sensitivity and depression in patients with hepatitis C virus

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Interferon-alpha-induced inflammation is associated with reduced glucocorticoid negative feedback sensitivity and depression in patients with hepatitis C virus

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作者：Jennifer C. Felger^a ; ^b ; ^{jfelger@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Ebrahim Haroon^a ; ^b ; Bobbi J. Woolwine^a ; Charles L. Raison^c ; ^d ; Andrew H. Miller^a ; ^b
关键词：HPA-axis ; Inflammation ; Hepatitis C virus ; Dexamethasone ; Depression ; Fatigue
刊名：Physiology & Behavior
出版年：2016
出版时间：1 November 2016
年：2016
卷：166
期：Complete
页码：14-21
全文大小：579 K

文摘

•: IFN-alpha decreased glucocorticoid sensitivity in association with flattened diurnal cortisol slope in patients with hepatitis C virus
•: Decreased glucocorticoid sensitivity was correlated with increased IFN-alpha-induced soluble tumor necrosis factor receptor 2 (sTNFR2)
•: Increased sTNFR2 predicted increased depression and fatigue scores, independent of the change in glucocorticoid sensitivity
•: Inflammation in medical illness may decrease glucocorticoid sensitivity, in turn increasing cytokines and their effects on behavior