Hippocampal adult neurogenesis: Does the immune system matter?

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• 作者：Aline Silva de Miranda^a ; ^b ; ^c ; ¹ ; ^{mirandas.aline@gmail.com} ; Cun-Jin Zhang^a ; ^d ; ¹ ; Atsuko Katsumoto^a ; Antô ; nio Lú ; cio Teixeira^c ; ^{altexr@gmail.com}
• 关键词：BAI1 ; brain-specific angiogenesis inhibitor 1 ; BDNF ; brain derived neurotrophic factor ; BRDU ; bromodeoxyuridine ; C3 ; complement component 3 ; CCL11 ; eotaxin ; Cq1 ; complement component 1 ; CR3 ; complement receptor 3 ; CSF-1R ; colony stimulating factor-1 receptor ; CX3CL1 ; fracktalkine ; DCX ; doublecortin ; DG ; dentate gyrus ; GITR ; glucocorticoid-induced tumor necrosis factor (TNF) receptor ; HUCB ; human umbilical cord blood ; IFN-γ ; interferon gamma ; IGF-1 ; insulin growth factor 1 ; IL-1 ; interleukin 1 ; I
• 刊名：Journal of the Neurological Sciences
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：372
• 期：Complete
• 页码：482-495
• 全文大小：836 K
• 卷排序：372

文摘

CNS resident and peripheral immune cells participate in adult neurogenesis. Microglia are closely associated with neural progenitor cells in the neurogenic niche. Fractalkine mediates neuron-microglia crosstalk in the neurogenic niche. Immune cells are associated with age-related decline of neurogenesis.