Inhibitory effects of fatty acid monoesters of 2-O-β--glucosylglycerol on Epstein–Barr virus activation

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• 作者：Colombo ; Diego ; Scala ; Antonio ; Taino ; Ida M. ; Toma ; Lucio ; Ronchetti ; Fiamma ; Tokuda ; Harukuni ; et. al.
• 关键词：Glycosylglycerols ; Cancer chemoprevention ; Anti-tumor promoters ; Epstein&ndash ; Barr virus early antigen
• 刊名：Cancer Letters
• 出版年：1998
• 出版时间：January 16, 1998
• 年：1998
• 卷：123
• 期：1
• 页码：83-86
• 全文大小：231 K

文摘

In a screening for cancer chemopreventing agents several glycosylglycerols were found to be active. In order to optimize the anti-tumor activity of this class of compounds, a series of 1-O-acyl-2-O-β--glucopyranosyl-sn-glycerols differing in the acyl chain length, which varied from C₄ to C₁₈, were examined for their in vitro anti-tumor promoting effects on Epstein–Barr virus early antigen (EBV-BA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). Among the compounds tested, the monohexanoyl derivative was the most active and, noteworthy, the most potent compound of the glycosylglycerol series hitherto known.