Arginine Deprivation Inhibits the Warburg Effect and Upregulates Glutamine Anaplerosis and Serine Biosynthesis in ASS1-Deficient Cancers

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• 作者：Jeff Charles Kremer¹ ; Bethany Cheree Prudner¹ ; Sara Elaine Stubbs Lange¹ ; Gregory Richard Bean¹ ; Matthew Bailey Schultze¹ ; Caitlyn Brook Brashears¹ ; Megan DeAnna Radyk¹ ; Nathan Redlich¹ ; Shin-Cheng Tzeng² ; Kenjiro Kami³ ; Laura Shelton⁴ ; Aixiao Li⁵ ; Zack Morgan⁵ ; John Stephen Bomalaski⁶ ; Takashi Tsukamoto⁷ ; Jon McConathy⁵ ; ⁸ ; ⁹ ; Loren Scott Michel¹ ; ⁸ ; Jason Matthew Held² ; ⁸ ; ¹⁰ ; Brian Andrew Van Tine¹ ; ⁸ ; ¹¹ ; ^{bvantine@wustl.edu}
• 关键词：sarcoma ; cancer metabolism ; Warburg effect ; glutamine anaplerosis ; serine biosynthesis ; argininosuccinate synthetase 1 ; arginine deprivation ; serine ; arginine ; glutamine
• 刊名：Cell Reports
• 出版年：2017
• 出版时间：24 January 2017
• 年：2017
• 卷：18
• 期：4
• 页码：991-1004
• 全文大小：5081 K
• 卷排序：18

文摘

ADI-PEG20 upregulates glutamine anaplerosis and oxidative phosphorylation Targeting glutamine metabolism with ADI-PEG20 induces synthetic lethality Arginine deprivation causes ASS1 deficient cells to upregulate serine biosynthesis Acquired resistance to ADI-PEG20 sensitizes to inhibition of serine metabolism