10">Binding process nintedanib to human Alpha-1 acid glycoprotein under simulated physiological conditions were studied.

15">Alpha-1 acid glycoprotein (AAG) is a major acute phase reactant, a major glycoprotein of the human plasma.

Secondary and tertiary structure alterations in the protein were observed and there is reduction in the hydrodynamic radii of the protein.

Dynamic molecular docking was performed.

Docking study show that nintidanib and two commonly used anticancer compounds clofarabine and methotrexate revealed overlapping regions.