Co-delivery of multiple drug resistance inhibitors by polymer/inorganic hybrid nanoparticles to effectively reverse cancer drug resistance

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• 作者：Cong Wu¹ ; Meng-Qing Gong¹ ; Bo-Ya Liu ; Ren-Xi Zhuo ; Si-Xue Cheng ; ^{chengsixue@whu.edu.cn} ; ^{chengsixue@hotmail.com}
• 关键词：Hybrid nanoparticles ; Multiple drug resistance ; Drug resistance inhibitor ; Co-delivery ; Immunostimulatory effects
• 刊名：Colloids and Surfaces B: Biointerfaces
• 出版年：2017
• 出版时间：1 January 2017
• 年：2017
• 卷：149
• 期：Complete
• 页码：250-259
• 全文大小：2522 K
• 卷排序：149

文摘

A multifunctional drug delivery platform based on hybrid nanopartricles was developed. Functional components were introduced to polymer/inorganic hybrid carriers by self-assembly. Co-delivery of drug resistance inhibitors resulted in significantly decreased P-gp and GSH. Co-delivery of multiple drug resistance inhibitors can effectively reverse drug resistance.