Long-term inhibition of cyclophilin D results in intracellular translocation of calcein AM from mitochondria to lysosomes

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• 作者：Daisuke Shinohe<sup>1sup> ; Asuka Kobayashi<sup>1sup> ; Marina Gotoh ; Kotaro Tanaka ; Yoshihiro Ohta<sup> ; sup><sup>ohta@cc.tuat.ac.jpsup>
• 关键词：Cyclophilin D ; Calcein AM ; Mitochondria ; Lysosomes
• 刊名：Archives of Biochemistry and Biophysics
• 出版年：2017
• 出版时间：1 January 2017
• 年：2017
• 卷：613
• 期：Complete
• 页码：53-60
• 全文大小：1432 K
• 卷排序：613

文摘

Calcein AM enters the mitochondria in C6 and HeLa cells. Calcein AM enters lysosomes upon long-term inhibition of cyclophilin D. Transport of calcein AM to lysosomes depends on cellular energy metabolism. Translocation to lysosomes occurs in a cargo-specific manner.