Systems Structural Biology Analysis of Ligand Effects on ERα Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies

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• 作者：Jerome C. Nwachukwu¹ ; Sathish Srinivasan¹ ; Nelson E. Bruno¹ ; Jason Nowak¹ ; Nicholas J. Wright¹ ; Filippo Minutolo² ; Erumbi S. Rangarajan¹ ; Tina Izard¹ ; Xin-Qui Yao³ ; Barry J. Grant³ ; Douglas J. Kojetin⁴ ; Olivier Elemento⁵ ; John A. Katzenellenbogen⁶ ; Kendall W. Nettles¹ ; ⁷ ; ^{knettles@scripps.edu}
• 关键词：nuclear receptor ; steroid hormone ; endocrine disruptor ; estrogen receptor-α ; breast cancer ; X-ray crystallography ; allosteric signaling
• 刊名：Cell Chemical Biology
• 出版年：2017
• 出版时间：19 January 2017
• 年：2017
• 卷：24
• 期：1
• 页码：35-45
• 全文大小：3029 K
• 卷排序：24

文摘

Environmental estrogens form structurally distinct complexes with ERα Allosteric signals occur with within the noise of typical ERα structures Comparison of many structures allows super-resolution analysis of ligand effects Specific interatomic distances in ERα predict cellular response to diverse ligands