Recent H3N2 Viruses Have Evolved Specificity for Extended, Branched Human-type Receptors, Conferring Potential for Increased Avidity

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• 作者：Wenjie Peng¹ ; ⁵ ; Robert P. de Vries¹ ; ⁵ ; ⁶ ; Oliver C. Grant² ; Andrew J. Thompson¹ ; Ryan McBride¹ ; Buyankhishig Tsogtbaatar¹ ; Peter S. Lee³ ; ⁷ ; Nahid Razi¹ ; Ian A. Wilson³ ; ⁴ ; Robert J. Woods² ; James C. Paulson¹ ; ⁸ ; ^{jpaulson@scripps.edu}
• 关键词：influenza virus ; H3N2 ; hemagglutinin ; receptor specificity ; airway ; chemo-enzymatic synthesis ; sialoside microarray ; extended branched glycans ; poly-N-acetyl-lactosamine ; bidentate binding
• 刊名：Cell Host & Microbe
• 出版年：2017
• 出版时间：11 January 2017
• 年：2017
• 卷：21
• 期：1
• 页码：23-34
• 全文大小：4412 K
• 卷排序：21

文摘

All H3N2 influenza viruses recognize human-type receptors with extended glycan chains Recent H3 and pandemic H1 hemagglutinins prefer extended, branched N-glycan receptors Lipid-linked glycan receptors restore infectivity to receptor-deficient MDCK cells Molecular dynamics simulation shows bidentate binding of N-glycans to one HA trimer