Predictive Polymer Modeling Reveals Coupled Fluctuations in Chromosome Conformation and Transcription

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Predictive Polymer Modeling Reveals Coupled Fluctuations in Chromosome Conformation and Transcription

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作者：Luca Giorgetti¹ ; ² ; ³ ; Rafael Galupa¹ ; ² ; ³ ; Elphè ; ge P. Nora¹ ; ⁷ ; Tristan Piolot¹ ; ² ; ³ ; France Lam¹ ; ² ; ³ ; Job Dekker⁴ ; Guido Tiana⁵ ; ^{guido.tiana@unimi.it" class="auth_mail} ; Edith Heard¹ ; ² ; ³ ; ⁶ ; ^{edith.heard@curie.fr" class="auth_mail}
刊名：Cell
出版年：8 May 2014
年：2014
卷：157
期：4
页码：950-963
全文大小：2975 K

文摘

•: Physical modeling deconvolves 5C data into single-cell chromosome conformations
•: Model and FISH validation reveal nonrandom structural variability in single TADs
•: Model predicts key loci for TAD internal structure that were genetically validated
•: Alternative TAD structures predict alternative transcription states in single cells

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