The activation of the NF-κB-JNK pathway is independent of the PI3K-Rac1-JNK pathway involved in the bFGF-regulated human fibroblast cell migration

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The activation of the NF-κB-JNK pathway is independent of the PI3K-Rac1-JNK pathway involved in the bFGF-regulated human fibroblast cell migration

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作者：Yuanhu Xuan^a ; ¹ ; Lisha Chi^a ; ¹ ; Haishan Tian^a ; ¹ ; Wanhui Cai^a ; Congcong Sun^a ; Tao Wang^a ; Xuan Zhou^b ; Minglong Shao^a ; Yuting Zhu^a ; Chao Niu^a ; Yusheng Sun^c ; Weitao Cong^a ; Zhongxin Zhu^a ; Zhaoyu Li^a ; Yang Wang^d ; ^{wy2010@wzmc.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Litai Jin^a ; ^{jin_litai@126.com" class="auth_mail" title="E-mail the corresponding author}
关键词：bFGF ; basic Fibroblast Growth Factor ; NF-κB ; nuclear factor kappa B ; c-JNK ; Jun N-terminal kinase ; PI3 K ; phosphatidylinositol 3-kinase ; FGFR ; fibroblast growth factor receptor ; RNA-Seq ; RNA-Sequencing ; IκB-α ; inhibitor of nuclear factor kappa B-alpha ; ECM ; extracellular matrix ; PKC ; protein kinase C ; ERK ; extracellular regulated protein kinases ; MAPK ; mitogen-activated protein kinase ; PAI-1 ; plasminogen activator inhibitor-1 ; TNF-α ; tumor necrosis factor ; GAPDH ; glyceraldehyde-3-phosphate dehyd
刊名：Journal of Dermatological Science
出版年：2016
出版时间：April 2016
年：2016
卷：82
期：1
页码：28-37
全文大小：3460 K

文摘

•: RNA-Seq based transcriptome analysis was introduced to isolate bFGF-regulating signal pathways that regulate cell migration.
•: Many pathways including Wnt, Hippo, ECM, Hedgehog, and NF-κB signaling pathways are regulated by bFGF signaling.
•: We identified bFGF-NF-κB-JNK pathway by which fibroblast cell migration is regulated.
•: NF-κB pathway regulates JNK activity is independent of the PI3K-Rac1 signaling pathway.

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