We conducted a longitudinal study of unipolar depressions before and after antidepressant medication treatment.
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We analyzed a hub-level community structure network by permutation network framework.
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Antidepressant medication (AM) therapy may promote the modulation of modular structure of hubs in the fronto-limbic circuit.
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The inter-module connections of the right medial superior frontal gyrus is a potential indicator for AM therapy response.
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