Continuous Histone Replacement by Hira Is Essential for Normal Transcriptional Regulation and De Novo DNA Methylation during Mouse Oogenesis

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Continuous Histone Replacement by Hira Is Essential for Normal Transcriptional Regulation and De Novo DNA Methylation during Mouse Oogenesis

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作者：Buhe Nashun¹ ; Peter W.S. Hill¹ ; Sebastien A. Smallwood² ; Gopuraja Dharmalingam¹ ; Rachel Amouroux¹ ; Stephen J. Clark² ; Vineet Sharma¹ ; ³ ; Elodie Ndjetehe¹ ; Pawel Pelczar⁴ ; ⁶ ; Richard J. Festenstein¹ ; ³ ; Gavin Kelsey² ; ⁵ ; Petra Hajkova¹ ; ^{petra.hajkova@csc.mrc.ac.uk" class="auth_mail" title="E-mail the corresponding author}
刊名：Molecular Cell
出版年：2015
出版时间：19 November 2015
年：2015
卷：60
期：4
页码：611-625
全文大小：4435 K

文摘

•: Histone H3/H4 replacement is continuous and mediated by Hira during mouse oogenesis
•: Loss of Hira results in chromatin abnormalities and extensive oocyte loss
•: Hira depletion reduces histone load, which prevents normal transcriptional regulation
•: Hira-mediated histone replacement is required for normal 5mC deposition in oocytes

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