The roles of Chk 1 and Chk 2 in hypoxia and reoxygenation

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• 作者：Ester M. Hammond ; Rachel A. Freiberg and Amato J. Giaccia
• 关键词：Hypoxia ; Reoxygenation ; Chk 1 ; Chk 2
• 刊名：Cancer Letters
• 出版年：2006
• 出版时间：18 July 2006
• 年：2006
• 卷：238
• 期：2
• 页码：161-167
• 全文大小：169 K

文摘

Both Chk 1 and Chk 2 are critically important checkpoint kinases. Chk 1 is an essential gene that is required for normal cell division and Chk 2 has been found to be mutated in an ever-growing list of human malignancies. Our recent studies indicate that both Chk 1 and Chk 2 have roles to play in the physiological stress of hypoxia/reoxygenation. Loss or inhibition of either kinase sensitizes cells to hypoxia/reoxygenation indicating that either or both could represent significant therapeutic targets.