The Sel1L-Hrd1 Endoplasmic Reticulum-Associated Degradation Complex Manages a Key Checkpoint in B Cell Development

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The Sel1L-Hrd1 Endoplasmic Reticulum-Associated Degradation Complex Manages a Key Checkpoint in B Cell Development

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作者：Yewei Ji¹ ; ⁵ ; ⁶ ; Hana Kim² ; ⁵ ; ⁶ ; Liu Yang¹ ; Haibo Sha¹ ; ⁷ ; Christopher A. Roman³ ; Qiaoming Long⁴ ; Ling Qi¹ ; ² ; ⁶ ; ⁸ ; ^{lingq@med.umich.edu" class="auth_mail" title="E-mail the corresponding author}
关键词：endoplasmic reticulum-associated degradation ; Sel1L ; Hrd1 ; B cell development ; pre-B cell receptor ; large pre-B cells
刊名：Cell Reports
出版年：2016
出版时间：6 September 2016
年：2016
卷：16
期：10
页码：2630-2640
全文大小：3614 K

文摘

•: ERAD deficiency blocks the transition from large pre-B cells to small pre-B cells
•: ERAD manages a B cell developmental checkpoint by attenuating pre-BCR signaling
•: The pre-BCR complex is an endogenous Sel1L-Hrd1 ERAD substrate in B cells
•: Pre-BCR degradation by the Sel1L-Hrd1 complex requires the ER chaperone BiP

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