3′-Geranyl-mono-substituted chalcone Xanthoangelovl induces apoptosis in human leukemia K562 cells via activation of mitochondrial pathway

详细信息    查看全文

• 作者：Yuou Teng ; Lixin Wang ; Huan Liu ; Yuan Yuan ; Qian Zhang ; Meng Wu ; Luyao Wang ; Haomeng Wang ; Zhen Liu ; ^{liuzhen5957@163.com} ; Peng Yu ; ^{yupeng@tust.edu.cn}
• 关键词：Chalcones ; Apoptosis ; Caspase-3 ; Bcl-2
• 刊名：Chemico-Biological Interactions
• 出版年：2017
• 出版时间：5 January 2017
• 年：2017
• 卷：261
• 期：Complete
• 页码：103-107
• 全文大小：1195 K
• 卷排序：261

文摘

3′-Geranyl-mono-substituted chalcone Xanthoangelol (1b) had potent cytotoxicity. Compound 1b affects the mitochondrial functions. Compound 1b inhibits K562 cell proliferation via mitochondria-mediated apoptosis.