Lymphocyte Circadian Clocks Control Lymph Node Trafficking and Adaptive Immune Responses

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• 作者：David Druzd¹ ; ¹¹ ; Olga Matveeva² ; ¹¹ ; Louise Ince¹ ; Ute Harrison³ ; Wenyan He¹ ; Christoph Schmal⁴ ; Hanspeter Herzel⁵ ; Anthony H. Tsang² ; Naoto Kawakami⁶ ; Alexei Leliavski⁷ ; Olaf Uhl⁸ ; Ling Yao⁹ ; Leif Erik Sander⁹ ; Chien-Sin Chen¹ ; Kerstin Kraus¹ ; Alba de Juan¹ ; Sophia Martina Hergenhan¹ ; Marc Ehlers⁷ ; Berthold Koletzko⁸ ; Rainer Haas³ ; Werner Solbach¹⁰ ; Henrik Oster² ; Christoph Scheiermann¹ ; ¹² ; ^{christoph.scheiermann@med.uni-muenchen.de}
• 关键词：circadian rhythm ; leukocyte trafficking ; adaptive immune response ; lymph node homing ; lymph node egress ; immunization
• 刊名：Immunity
• 出版年：2017
• 出版时间：17 January 2017
• 年：2017
• 卷：46
• 期：1
• 页码：120-132
• 全文大小：2702 K
• 卷排序：46

文摘

Lymphocyte numbers in lymph nodes and lymph oscillate over the course of the day Rhythmic Ccr7 and S1pr1 expression drives rhythmic lymphocyte homing and egress Adaptive immune responses to immunization and pathogens are time-of-day dependent Loss of circadian clocks in lymphocytes ablates rhythmic adaptive immune responses