Riluzole promotes motor and respiratory recovery associated with enhanced neuronal survival and function following high cervical spinal hemisection

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Riluzole promotes motor and respiratory recovery associated with enhanced neuronal survival and function following high cervical spinal hemisection

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作者：K. Satkunendrarajah^a ; F. Nassiri^a ; S.K. Karadimas^b ; A. Lip^a ; G. Yao^a ; M.G. Fehlings^a ; ^b ; ^{michael.fehlings@uhn.ca" class="auth_mail" title="E-mail the corresponding author}
关键词：Riluzole ; Cervical spinal cord injury ; Neuroprotection ; Functional outcomes
刊名：Experimental Neurology
出版年：2016
出版时间：February 2016
年：2016
卷：276
期：Complete
页码：59-71
全文大小：1805 K

文摘

•: High cervical hemisection injury reduces synaptic connectivity to caudal neurons.
•: This injury leads to caudal motoneuron loss that is limited by riluzole treatment.
•: Riluzole enhances glutamate receptor expression and excitability of caudal motoneurons.
•: Modulation of glutamate receptors leads to respiratory and forelimb motor recovery.

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