Aminoguanidine treatment increased NOX2 response in diabetic rats: Improved phagocytosis and killing of Candida albicans by neutrophils

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Aminoguanidine treatment increased NOX2 response in diabetic rats: Improved phagocytosis and killing of Candida albicans by neutrophils

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作者：Clá ; udia de Souza Ferreira^a ; Paula Commune Pennacchi^a ; Tomaz Henrique Araú ; jo^b ; Noemi Nosomi Taniwaki^c ; Fernanda Borges de Araú ; jo Paula^a ; Stella Maris da Silveira Duarte^a ; Maria Rita Rodrigues^a ; ^{mritar11@yahoo.com.br" class="auth_mail" title="E-mail the corresponding author}
关键词：AGEs ; Advanced glycation end products ; AMG ; Aminoguanidine ; DM ; Diabetes mellitus ; HbA1c ; glycated hemoglobin ; HOCl ; hypochlorous acid ; NO ; Nitric oxide ; iNOS ; Nitric oxide synthase ; NOX2 ; phagocyte NADPH oxidase system ; ROS ; Reactive oxygen species ; ONOO- ; peroxynitrite ; PKC ; protein kinase C ; MPO ; myeloperoxidase
刊名：European Journal of Pharmacology
出版年：2016
出版时间：5 February 2016
年：2016
卷：772
期：Complete
页码：83-91
全文大小：1735 K

文摘

•: The AMG increases the microbicidal activity of neutrophils against C. albicans
•: The AMG modulates the response NOX2 against C. albicans
•: Increased NOX2 by AMG was independent of the diabetic state and MPO activity.

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