Development and validation of an UHPLC method for the determination of betamethasone valerate in cream, gel, ointment and lotion

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Development and validation of an UHPLC method for the determination of betamethasone valerate in cream, gel, ointment and lotion

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作者：Lí ; lian Grace da Silva Solon^a ; Igor Prado de Barros Lima^a ; Fernando Henrique Andrade Nogueira^a ; Jailton Paulo de Araú ; jo^b ; Carla Almeida Vivacqua^b ; Cí ; cero Flá ; vio Soares Aragã ; o^a ; ^{cicero.aragao@yahoo.com.br" class="auth_mail" title="E-mail the corresponding author}
关键词：Betamethasone valerate ; Dermatologic formulations ; DoE ; Three-level factorial design ; UHPLC
刊名：Steroids
出版年：2016
出版时间：February 2016
年：2016
卷：106
期：Complete
页码：70-77
全文大小：1571 K

文摘

•: UHPLC method was developed and validated for betamethasone valerate in topical formulations: cream, gel, ointment and lotion.
•: The chromatographic conditions were the main points investigated.
•: A 3³ full factorial design was employed to estimate the model coefficients.
•: The method offers advantages in terms of analysis speed.

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