Are HLA-DR or TAP Genes Genetic Markers of Severity in Ulcerative Colitis?

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• 作者：Heresbach ; Denis ; Alizadeh ; Mehdi ; Reumaux ; Dominique ; Colombel ; Jean-Fré ; dé ; ric ; et. al.
• 刊名：Journal of Autoimmunity
• 出版年：1996
• 出版时间：December, 1996
• 年：1996
• 卷：9
• 期：6
• 页码：777-784
• 全文大小：137 K

文摘

The pathogeny of ulcerative colitis (UC) is not yet elucidated, but some arguments suggest the implication of genetic factors. Among the candidate genes, those encoding for HLA class II genotypes have been extensively studied in UC; however, discordant data may be imputable to heterogeneity, characterized by immunological markers such as atypical ANCA (p-ANCA), or to inclusion of more or less intractable UC. The aim of our study is to evaluate the interest of HLA class II and TAP genetic markers to identify different clinical forms of UC, according to p-ANCA status. Unrelated patients with a history of UC (n