Synthesis of phosphorus containing medium ring heterocycles by sequential Claisen rearrangement and ring closing metathesis

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• 作者：K.C. Majumdar ; Raj Kumar N ; i ; Sintu Ganai
• 关键词：Phosphorus heterocycles ; Medium-sized ring ; Claisen rearrangement ; Grubb&rsquo ; s I catalyst ; Ring closing metathesis
• 刊名：Tetrahedron Letters
• 出版年：5 February, 2014
• 年：2014
• 卷：55
• 期：6
• 页码：1247-1250
• 全文大小：1518 K

文摘

An efficient method for the synthesis of novel medium ring phosphorus containing heterocycles starting from phenol derivatives by ruthenium catalyzed ring closing metathesis is described. This work deals with a sequential aromatic Claisen-rearrangement, coupling of an allyl/vinyl phosphonate, and ring closing metathesis reaction. All of these reactions were carried out at ambient temperature to afford the medium-sized phosphorus heterocycles in excellent yields.