Catalysis by Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase (PfHGXPRT) is modulated by oligomerization and peptide bond isomerization.

PfHGXPRT follows steady-state ordered mechanism displaying absence of burst phase in pre-steady-state progress curves.

The rate limiting step is a step prior to catalysis in PfHGXPRT while in human HGPRT it is product release.

Human and PfHG(X)PRT show distinctly different kinetic mechanisms.