Composition and Antigenic Effects of Individual Glycan Sites of a Trimeric HIV-1 Envelope Glycoprotein

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Composition and Antigenic Effects of Individual Glycan Sites of a Trimeric HIV-1 Envelope Glycoprotein

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作者：Anna-Janina Behrens¹ ; Snezana Vasiljevic¹ ; Laura K. Pritchard¹ ; David J. Harvey¹ ; Rajinder S. Andev² ; Stefanie A. Krumm² ; Weston B. Struwe¹ ; Albert Cupo³ ; Abhinav Kumar¹ ; Nicole Zitzmann¹ ; Gemma E. Seabright¹ ; Holger B. Kramer⁴ ; Daniel I.R. Spencer⁵ ; Louise Royle⁵ ; Jeong Hyun Lee⁶ ; Per J. Klasse³ ; Dennis R. Burton⁷ ; ⁸ ; Ian A. Wilson⁶ ; ⁹ ; Andrew B. Ward⁶ ; Rogier W. Sanders³ ; ¹⁰ ; John P. Moore³ ; Katie J. Doores² ; ^{katie.doores@kcl.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Max Crispin¹ ; ^{max.crispin@bioch.ox.ac.uk" class="auth_mail" title="E-mail the corresponding author}
刊名：Cell Reports
出版年：2016
出版时间：22 March 2016
年：2016
卷：14
期：11
页码：2695-2706
全文大小：4061 K

文摘

•: Quantitative, site-specific N-glycan analysis of a soluble HIV-1 Env trimer
•: A map of the extremes of simplicity and diversity at individual glycan sites
•: The fine structure of the mannose patch area of the Env trimer
•: How individual glycan sites influence HIV-1 Env-pseudovirus neutralization

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