Systemic expression of inflammatory mediators in patients with chronic rhinosinusitis and nasal polyps with and without Aspirin Exacerbated Respiratory Disease

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Systemic expression of inflammatory mediators in patients with chronic rhinosinusitis and nasal polyps with and without Aspirin Exacerbated Respiratory Disease

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作者：Rogerio Pezato^a ; ^b ; Monika Świerczyńska-Krępa^c ; Ewa Niżankowska-Mogilnicka^d ; Gabriele Holtappels^a ; Natalie De Ruyck^a ; Marek Sanak^d ; Lara Derycke^a ; Koen Van Crombruggen^a ; Claus Bachert^a ; Claudina A. Pé ; rez-Novo^a ; ^{Claudina.Pereznovo@UGent.be" class="auth_mail" title="E-mail the corresponding author}
关键词：Aspirin Exacerbated Respiratory Disease ; Interleukin 6 ; Memory T-cells ; Oral aspirin challenge ; Systemic reaction after aspirin challenge ; Interleukin 8 ; IL-5 receptor alpha ; TGF-β1
刊名：Cytokine
出版年：2016
出版时间：January 2016
年：2016
卷：77
期：Complete
页码：157-167
全文大小：1392 K

文摘

•: Patients with AERD may have a deficiency in T-regulatory mechanisms.
•: AERD patients showed higher baseline levels of s-IL-5R-alpha, uLTE₄.
•: Aspirin challenge induced increase of IL-6 and memory T-cells in AERD patients.