Design, synthesis and antifungal activity of novel fenfuram-diarylamine hybrids

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• 作者：Hongyu Wang ; Xuheng Gao ; Xiaoxiao Zhang ; Hong Jin ; ^{jinhong@scu.edu.cn} ; Ke Tao ; Taiping Hou ; ^{houtplab@scu.edu.cn}
• 关键词：Fenfuram-diarylamine hybrid ; Synthesis ; Antifungal activity ; Molecular docking
• 刊名：Bioorganic & Medicinal Chemistry Letters
• 出版年：2017
• 出版时间：1 January 2017
• 年：2017
• 卷：27
• 期：1
• 页码：90-93
• 全文大小：1445 K
• 卷排序：27

文摘

Ten novel fenfuram-diarylamine hybrids were designed and synthesized. And their antifungal activities against four phytopathogenic fungi have been evaluated in vitro and most of the compounds demonstrated a significant antifungal activities against Rhizoctonia solani and Sclerotinia sclerotiorum. Compound 5e exhibited the most potent antifungal activity against R. solani with an EC50 value of 0.037 mg/L, far superior to the commercially available fungicide boscalid (EC50 = 1.71 mg/L) and lead fungicide fenfuram (EC50 = 6.18 mg/L). Furthermore, scanning electron microscopy images showed that the mycelia on treated media grew abnormally with tenuous, wizened and overlapping colonies compared to the negative control. Molecular docking studies revealed that compound 5e featured a higher affinity for succinate dehydrogenase (SDH) than fenfuram. Furthermore, it was shown that the 3-chlorophenyl group in compound 5e formed a CH-π interaction with B/Trp-206 and a Cl-π interaction with D/Tyr-128, rendering compound 5e more active than fenfuram against SDH.