Bidirectional relationship of mast cells-neurovascular unit communication in neuroinflammation and its involvement in POCD

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• 作者：Nana Li¹ ; Xiang Zhang¹ ; Hongquan Dong¹ ; Youli Hu ; Yanning Qian ; ^{yanning_qian@163.com}
• 关键词：POCD ; postoperative cognitive dysfunction ; AD ; Alzheimer&rsquo ; s disease ; PD ; Parkinson&rsquo ; s disease ; MS ; multiple sclerosis ; ALS ; amyotrophic lateral sclerosis ; MCs ; mast cells ; CNS ; central nervous system ; CSF ; cerebrospinal fluid ; NVU ; neurovascular unit ; BBB ; blood-brain barrier ; VSMCs ; vascular smooth muscle cells ; TNF-α ; tumor necrosis ; IL-1β ; interleukin-1β ; IL-4 ; interleukin-4 ; IL-6 ; interleukin-6 ; IL-33 ; interleukin-33 ; IL-13 ; interleukin-13 ; IL17A ; interleukin 17A ; HMGB1 ; high-mobil
• 刊名：Behavioural Brain Research
• 出版年：2017
• 出版时间：30 March 2017
• 年：2017
• 卷：322
• 期：part_PA
• 页码：60-69
• 全文大小：1875 K
• 卷排序：322

文摘

Neuroinflammation is involved in the development of postoperative cognitive dysfunction. Activated Mast cells contribute to the progress of neuroinflammation. Mast cells-neurovascular unit communication promotes the pathological process of neuroinflammation and cognitive dysfunction.