DNA vaccines for HFRS: Laboratory and clinical studies

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DNA vaccines for HFRS: Laboratory and clinical studies

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作者：Connie S. Schmaljohn ; ^{connie.schmaljohn@us.army.mil" class="auth_mail} ; Kristin W. Spik ; Jay W. Hooper
关键词：Hemorrhagic fever with renal syndrome ; Hantaviruses ; DNA vaccine ; Electroporation ; Phase 1 clinical study
刊名：Virus Research
出版年：17 July 2014
年：2014
卷：187
期：Complete
页码：91-96
全文大小：925 K

文摘

•: We tested individual and combined HTNV and PUUV DNA vaccines in human subjects.
•: We showed that both DNA vaccines are safe in humans.
•: We observed immune interference between the vaccines.
•: We overcame immune interference by optimizing the HTNV gene construct.

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