Basal cells express functional TRPV4 channels in the mouse nasal epithelium

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Basal cells express functional TRPV4 channels in the mouse nasal epithelium

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作者：Takashi Ueda ; ^{tueda@med.nagoya-cu.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Mariko Hoshikawa ; Yasuhiro Shibata ; Natsuko Kumamoto ; Shinya Ugawa
关键词：Transient receptor potential vanilloid type 4 (TRPV4) ; Basal cells ; Nasal epithelium ; Immunohistochemistry ; Calcium imaging ; Mouse
刊名：Biochemistry and Biophysics Reports
出版年：2015
出版时间：December 2015
年：2015
卷：4
期：Complete
页码：169-174
全文大小：2029 K

文摘

•: TRPV4 is expressed in basal stem cells of the nasal airway and olfactory epithelium.
•: TRPV4 expression appears in the nasal epithelium during the late prenatal stages.
•: TRPV4 activation causes an increase in cytosolic Ca²⁺ concentration.
•: TRPV4 may be involved in a variety of cellular functions in progenitor/stem cells.

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