Antagonistic Effects of BACE1 and APH1B-纬-Secretase Control Axonal Guidance by Regulating Growth Cone Collapse

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Antagonistic Effects of BACE1 and APH1B-纬-Secretase Control Axonal Guidance by Regulating Growth Cone Collapse

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作者：Soraia Barã ; o¹ ; ² ; Annette Gä ; rtner¹ ; ² ; Eduardo Leyva-Dí ; az⁴ ; Galina Demyanenko⁵ ; Sebastian Munck¹ ; ² ; Tine Vanhoutvin¹ ; ² ; Lujia Zhou¹ ; ² ; Melitta Schachner⁶ ; ⁷ ; Guillermina Ló ; pez-Bendito⁴ ; Patricia F. Maness⁵ ; Bart De Strooper¹ ; ² ; ³ ; ^{bart.destrooper@cme.vib-kuleuven.be" class="auth_mail" title="E-mail the corresponding author}
刊名：Cell Reports
出版年：2015
出版时间：1 September 2015
年：2015
卷：12
期：9
页码：1367-1376
全文大小：2862 K

文摘

•: BACE1 and 纬-secretase act in a cycle that regulates axonal outgrowth
•: CHL1CTF尾 production by BACE1 is essential for Sema3A-induced growth cone collapse
•: Subsequent APH1B-纬-secretase is needed to terminate the growth cone collapse

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