MiR-18b suppresses high-glucose-induced proliferation in HRECs by targeting IGF-1/IGF1R signaling pathways

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MiR-18b suppresses high-glucose-induced proliferation in HRECs by targeting IGF-1/IGF1R signaling pathways

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作者：Jin-hui Wu^a ; ^{wjhchanghai@163.com" class="auth_mail" title="E-mail the corresponding author} ; Yi-han Wang^b ; Wei Wang^c ; Wei Shen^a ; Yan-zhi Sang^a ; Lin Liu^b ; Cui-min Chen^d ; ^{535428425@qq.com" class="auth_mail" title="E-mail the corresponding author}
关键词：DR ; diabetic retinopathy ; PDR ; proliferative diabetic retinopathy ; HRECs ; human retinal endothelial cells ; REC ; retinal microvascular endothelial cell ; VEGF ; vascular endothelial growth factor ; IGF-1 ; insulin growth factor-1 ; IGF1R ; insulin growth factor-1 receptor ; miRNAs ; microRNAs ; miR-18a/b ; microRNA-18a/b ; 3&prime ; UTR ; 3&prime ; untranslated region ; PI3K ; phosphatidylinositol 3 kinase ; MAPK ; mitogen-activated protein kinase ; AKT ; v-akt murine thymoma viral oncogene homolog ; Ki67 ; antigen iden
刊名：International Journal of Biochemistry and Cell Biology
出版年：2016
出版时间：April 2016
年：2016
卷：73
期：Complete
页码：41-52
全文大小：3298 K

文摘

•: High glucose promotes HRECs proliferation by downregulating miR-18b.
•: MiR-18b directly target 3′ UTR of human IGF-1 in vitro.
•: Activation of IGF-1/IGF1R pathway mediates the effect of miR-18b on proliferation and VEGF production.
•: Overexpression of miR-18b might offer novel therapeutic options for DR.

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