Potential suppression of the high glucose and insulin-induced retinal neovascularization by Sirtuin 3 in the human retinal endothelial cells

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• 作者：Xin-Bang Mao ; Zhi-Peng You ; ^{yzpengy@163.com} ; Chen Wu ; Jun Huang
• 关键词：Sirtuin 3 ; Neovascularization ; Retinal endothelial cells ; Migration ; Autophagy
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：8 January 2017
• 年：2017
• 卷：482
• 期：2
• 页码：341-345
• 全文大小：813 K
• 卷排序：482

文摘

Retinal neovascularization model was established by treating HRECs with high glucose and insulin (HGI). Sirt3 inhibited HGI-induced expression of migration-related genes, including MMP-2 and MMP-9. Sirt3 inhibited HGI-induced expression of angiogenesis-related genes, including VEGF, HIF-1α, and IGF-1. Sirt3 promoted the expression of an autophagy gene, LC3, under HGI induction. Sirt3 may inhibit HGI-induced retinal neovascularization by regulating cell migration and autophagy.