Efficacy and tolerability of long-term treatment with vagus nerve stimulation in adolescents and adults with refractory epilepsy and learning disabilities

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• 作者：Caroline Lund ; ^a ; ^{Caroline.lund@epilepsy.no} ; Hrisimir Kostov^a ; Berit Blomskjø ; ld^a ; Karl O. Nakken^a
• 关键词：Epilepsy ; Learning disability ; Vagus nerve stimulation
• 刊名：Seizure
• 出版年：2011
• 出版时间：January 2011
• 年：2011
• 卷：20
• 期：1
• 页码：34-37
• 全文大小：109 K

文摘

The long-term effects of vagus nerve stimulation (VNS) on seizure frequency were studied in 50 patients with epilepsy and learning disabilities. Mean observation time was 4.6 years. At follow-up, none of the patients was seizure-free, 25 % had more than 50 % seizure reduction, and 46 % had some seizure reduction, but less than 50 % . The discontinuation rate was 18 % . Our results indicate that, like antiepileptic drugs, VNS does not have such a good seizure-reducing effect in patients with epilepsy and learning disabilities compared with the general epilepsy population.