Interplay between Obesity-Induced Inflammation and cGMP Signaling in White Adipose Tissue

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• 作者：Abhishek Sanyal¹ ; ² ; Jennifer Naumann¹ ; Linda Sarah Hoffmann¹ ; ⁸ ; Agnieszka Chabowska-Kita¹ ; Anna Ehrlund³ ; Andreas Schlitzer⁴ ; ⁵ ; ⁶ ; Peter Arner³ ; Matthias Blü ; her⁷ ; Alexander Pfeifer¹ ; ² ; ⁹ ; ^{alexander.pfeifer@uni-bonn.de}
• 关键词：cGMP signaling ; sGC ; PKG ; metaflammation ; obesity ; TNF-α
• 刊名：Cell Reports
• 出版年：2017
• 出版时间：3 January 2017
• 年：2017
• 卷：18
• 期：1
• 页码：225-236
• 全文大小：4201 K
• 卷排序：18

文摘

Metaflammation impedes cGMP signaling in visceral, but not subcutaneous, WAT cGMP signaling dysregulation corresponds to the degree of WAT inflammation NF-κB and JNK signaling differentially regulate cGMP signaling component expression Status of metaflammation and cGMP signaling are alike in murine and human obesity