Asymmetric PI3K Signaling Driving Developmental and Regenerative Cell Fate Bifurcation

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Asymmetric PI3K Signaling Driving Developmental and Regenerative Cell Fate Bifurcation

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作者：Wen-Hsuan W. Lin¹ ; ⁴ ; William C. Adams¹ ; ⁴ ; Simone A. Nish¹ ; Yen-Hua Chen¹ ; Bonnie Yen¹ ; Nyanza J. Rothman¹ ; Radomir Kratchmarov¹ ; Takaharu Okada² ; Ulf Klein³ ; Steven L. Reiner¹ ; ^{sr2978@cumc.columbia.edu" class="auth_mail" title="E-mail the corresponding author}
刊名：Cell Reports
出版年：2015
出版时间：15 December 2015
年：2015
卷：13
期：10
页码：2203-2218
全文大小：5275 K

文摘

•: Plasma cells and effector T cells are produced during an asymmetric cell division
•: Production of differentiated lymphocytes is coupled to renewal of the progenitor cell
•: Unequal PI3K signaling during cell division bifurcates sibling fates
•: Unequal PI3K/AKT/mTOR intensity causes unequal FoxO1 inactivation in sibling cells

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