For Better or Worse: Cytosolic DNA Sensing during Intracellular Bacterial Infection Induces Potent Innate Immune Responses

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For Better or Worse: Cytosolic DNA Sensing during Intracellular Bacterial Infection Induces Potent Innate Immune Responses

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作者：Kristin L. Patrick^&dagger ; ; Samantha L. Bell^&dagger ; ; Robert O. Watson ; ^{robert.watson@medicine.tamhsc.edu" class="auth_mail" title="E-mail the corresponding author} ; ^{rowatson13@yahoo.com" class="auth_mail" title="E-mail the corresponding author}
关键词：dsDNA ; double-stranded DNA ; IFN ; interferon ; PAMPs ; pathogen-associated molecular patterns ; TLRs ; Toll-like receptors ; STING ; stimulator of interferon genes ; TBK1 ; tank-binding kinase 1 ; ISGs ; interferon-stimulated genes ; DAI ; DNA-dependent activator of IRFs ; ALRs ; AIM2-like receptors ; IFI16 ; interferon gamma-inducible protein 16 ; RIG-I ; retinoic acid-inducible gene 1 ; CGAMP ; cyclic GMP-AMP ; BMDMs ; bone marrow-derived macrophages ; DCs ; dendritic cells ; HSV1 ; herpes simplex virus ; IL-1β ; interleu
刊名：Journal of Molecular Biology
出版年：2016
出版时间：28 August 2016
年：2016
卷：428
期：17
页码：3372-3386
全文大小：542 K

文摘

•: Cytosolic DNA from intracellular bacteria is sensed by the innate immune system.
•: Bacterial DNA sensing requires the same molecules as viral DNA sensing.
•: Bacterial DNA sensing activates pro- and antibacterial immune responses

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