Serotonin Signaling through Prefrontal Cortex 5-HT_1A Receptors during Adolescence Can Determine Baseline Mood-Related Behaviors

详细信息    查看全文

• 作者：Alvaro L. Garcia-Garcia¹ ; Qingyuan Meng¹ ; Sarah Canetta² ; Alain M. Gardier³ ; Bruno P. Guiard³ ; Christoph Kellendonk² ; ⁴ ; ⁵ ; Alex Dranovsky¹ ; ^{ad722@cumc.columbia.edu} ; E. David Leonardo¹ ; ⁶ ; ^{el367@cumc.columbia.edu}
• 关键词：serotonin ; 5-HT1A ; depression ; anxiety ; development ; adolescence ; mPFC ; DRN
• 刊名：Cell Reports
• 出版年：2017
• 出版时间：31 January 2017
• 年：2017
• 卷：18
• 期：5
• 页码：1144-1156
• 全文大小：3729 K
• 卷排序：18

文摘

Loss of forebrain 5-HT1A receptors results in a depression-like phenotype Suppression of 5-HT1A heteroreceptors alters mPFC-DRN responses to stress Suppression of 5-HT1A heteroreceptors results in altered 5-HT tone Selective loss of mPFC 5-HT1A receptors at adolescence recapitulates the phenotype