Cultured human amniocytes express hTERT, which is distributed between nucleus and cytoplasm and is secreted in extracellular vesicles

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• 作者：Annalisa Radeghieri ; ¹ ; ^{annalisa.radeghieri@unibs.it} ; Giulia Savio¹ ; Andrea Zendrini ; Giuseppe Di Noto ; Alessandro Salvi ; Paolo Bergese ; Giovanna Piovani ; ^{giovanna.piovani@unibs.it}
• 关键词：Amniotic fluid cells ; hTERT ; Gene expression ; Intracellular distribution ; Extracellular vesicles
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：29 January 2017
• 年：2017
• 卷：483
• 期：1
• 页码：706-711
• 全文大小：818 K
• 卷排序：483

文摘

Primary cultures of AFCs express the gene hTERT at different levels. hTERT protein is present in the nuclear and cytoplasmic compartment of AFCs. Cytosolic hTERT is embodied in AFCs secreted extracellular vesicles. Those findings indicate a new potential extra telomeric role for hTERT. AFCs derived EVs might represent a useful tool for regenerative medicine.