Rifampin suppresses osteoclastogenesis and titanium particle-induced osteolysis via modulating RANKL signaling pathways

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• 作者：Liang Zhu^a ; ^b ; ¹ ; Hui Kang^b ; ¹ ; Chang-an Guo^a ; Wen-shuai Fan^a ; Yi-ming Wang^a ; Lian-fu Deng^b ; Zuo-qin Yan^a ; ^{zuoqin_yan@163.com}
• 关键词：Osteolysis ; Rifampin ; NF-κB ; P38 ; Wear particles
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：26 February 2017
• 年：2017
• 卷：484
• 期：1
• 页码：64-70
• 全文大小：2775 K
• 卷排序：484

文摘

Rifampin inhibited Ti-induced osteolysis and osteoclastogenesis in vivo. Rifampin suppressed osteoclast differentiation and bone resorption in a dose-dependent manner. Rifampin significantly reduced the expression of osteoclast-specific markers in vitro. RANKL-induced p38 and NF-κB signaling may be involved behind the effects of rifampin treatment on osteoclastogenesis.