Hepatitis C virus and non-Hodgkin’s lymphomas: A minireview

详细信息    查看全文

• 作者：Hussein Khaled^a ; ^{khussein528@gmail.com}Author Vitae ; Fouad Abu-Taleb^bAuthor Vitae ; Rasha Haggag^bAuthor Vitae
• 关键词：Hepatitis C virus ; Non-Hodgkin lymphoma ; Pathogenesis ; Antiviral treatment
• 刊名：Journal of Advanced Research
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：8
• 期：2
• 页码：131-137
• 全文大小：1080 K
• 卷排序：8

文摘

B-cell NHL is strongly associated with HCV that was proved in the last 2 decades. The most common HCV infection related B-NHL subtypes include MZL and DLBCL lymphomas. HCV-positive NHL patients usually present with older age at diagnosis, higher LDH, and more extranodal disease. The standard chemo-immunotherapy tolerance is generally good. Antiviral treatment achieves virological and hematological remission in HCV associated indolent lymphoma. More aggressive lymphoma requires combination of antiviral treatment and chemotherapy. New generation of HCV antiviral drugs is safe and is highly efficacious. Regimens including DAAs appear promising options as they can reduce the HCV-associated NHL incidence by dramatically lowering the HCV chronic carriers.