Glycosylated nordihydroguaiaretic acids as anti-cancer agents

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• 作者：Jih Ru Hwu ; Chuan-I Hsu ; Ming-Hua Hsu ; Yu-Chuan Liang ; Ru Chih C. Huang ; Yuan C. Lee
• 关键词：Nordihydroguaiaretic acid ; NDGA ; Hepatocellular carcinoma ; Triazol-glucose ; Triazol-galactose
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2011
• 出版时间：1 January 2011
• 年：2011
• 卷：21
• 期：1
• 页码：380-382
• 全文大小：264 K

文摘

Three perglycosylated nordihydroguaiaretic acids (NDGA) were synthesized through the Huiseng 1,3-dipolar cycloaddition reaction. These sugar–NDGA conjugates containing triazole-linkages possessed good solubility in water. NDGA-(triazol-galactose)₄ (12b) and NDGA-(triazol-glucose)₄ (12c) were found to act as inhibitors against human hepatocellular carcinoma Hep3B cells in culture.