17β-Hydroxysteroid dehydrogenase type 10 predicts survival of patients with colorectal cancer and affects mitochondrial DNA content

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17β-Hydroxysteroid dehydrogenase type 10 predicts survival of patients with colorectal cancer and affects mitochondrial DNA content

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作者：Albert Amberger^a ; ^{Albert.Amberger@i-med.ac.at" class="auth_mail" title="E-mail the corresponding author} ; Andrea J. Deutschmann^a ; Pia Traunfellner^a ; Patrizia Moser^b ; René ; G. Feichtinger^c ; Barbara Kofler^c ; Johannes Zschocke^a ; ^{Johannes.Zschocke@i-med.ac.at" class="auth_mail" title="E-mail the corresponding author}
关键词：Colorectal cancer ; Mitochondrial DNA ; Survival ; 17β-Hydroxysteroid dehydrogenase type 10 ; Prognostic marker
刊名：Cancer Letters
出版年：2016
出版时间：28 April 2016
年：2016
卷：374
期：1
页码：149-155
全文大小：1350 K

文摘

•: We examined expression of HSD10 in colorectal cancer.
•: HSD10 is an independent prognostic marker for survival.
•: HSD10 expression correlates with mitochondrial DNA content in cancer.
•: Decreased HSD10 expression causes mitochondrial DNA depletion in cancer cells.

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