Preparation of chitosan-based multifunctional nanocarriers overcoming multiple barriers for oral delivery of insulin

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Preparation of chitosan-based multifunctional nanocarriers overcoming multiple barriers for oral delivery of insulin

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作者：Lei Li^a ; Guohua Jiang^a ; ^b ; ^c ; ^{ghjiang_cn@zstu.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Weijiang Yu^a ; Depeng Liu^a ; Hua Chen^a ; Yongkun Liu^a ; Zaizai Tong^a ; Xiangdong Kong^d ; Juming Yao^a ; ^b ; ^c
关键词：Nanocarriers ; Chitosan ; Insulin ; Oral delivery ; Hypoglycemic effect
刊名：Materials Science & Engineering C
出版年：2017
出版时间：1 January 2017
年：2017
卷：70
期：part_P1
页码：278-286
全文大小：1616 K

文摘

•: Chitosan-based multifunctional nanocarriers for oral delivery of insulin were prepared.
•: The resultant nanocarriers exhibited low cytotoxicity against HT-29 cells.
•: The loaded insulin exhibited excellent stability against pepsin and pancreatin.
•: The hypoglycemic effect for oral delivery of insulin was studied in vivo.
•: The findings provide a new way in diabetes treatment via oral ingestion.

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