Chronic lymphocytic leukemia immunoglobulins display bacterial reactivity that converges and diverges from auto-/poly-reactivity and IGHV mutation status

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Chronic lymphocytic leukemia immunoglobulins display bacterial reactivity that converges and diverges from auto-/poly-reactivity and IGHV mutation status

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作者：Katerina Hatzi^a ; ¹ ; Rosa Catera^a ; Carolina Moreno Atanasio^a ; Vincent A. Fischetti^b ; Steven L. Allen^a ; ^c ; Jonathan E. Kolitz^a ; ^c ; Kanti R. Rai^a ; ^c ; Charles C. Chu^a ; ^c ; Nicholas Chiorazzi^a ; ^c ; ^{NChizzi@Northwell.edu" class="auth_mail" title="E-mail the corresponding author}
关键词：BCR ; B-cell receptor for antigen ; CLL ; Chronic lymphocytic leukemia ; IG ; Immunoglobulin ; FBS ; Fetal bovine serum ; IGHV ; IG heavy chain variable ; M-CLL ; IGHV-mutated chronic lymphocytic leukemia ; U-CLL ; IGHV-unmutated chronic lymphocytic leukemia ; mAbs ; Monoclonal antibodies ; GlcNAc ; N-acetylglucosamine ; OPD ; O-phenylenediamine dihydrochloride ; smIG ; Surface membrane immunoglobulin
刊名：Clinical Immunology
出版年：2016
出版时间：November 2016
年：2016
卷：172
期：Complete
页码：44-51
全文大小：471 K

文摘

•: In general, CLL IGs that bind multiple bacterial strains are auto-/poly-reactive.
•: Some mono-reactive bacterial IGs are auto-/poly-reactive.
•: Some broadly-reactive bacterial IGs are not auto-/poly-reactive
•: A few CLL IGs bound only one bacterial strain and these used the same IGKVs