Synthesis, antileishmanial activity and cytotoxicity of 2,3-diaryl- and 2,3,8-trisubstituted imidazo[1,2-a]pyrazines

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Synthesis, antileishmanial activity and cytotoxicity of 2,3-diaryl- and 2,3,8-trisubstituted imidazo[1,2-a]pyrazines

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作者：Pascal Marchand^a ; ^{pascal.marchand@univ-nantes.fr" class="auth_mail" title="E-mail the corresponding author} ; Marc-Antoine Bazin^a ; Fabrice Pagniez^b ; Guillaume Riviè ; re^a ; Lizeth Bodero^a ; Sophie Marhadour^a ; Marie-René ; e Nourrisson^a ; Carine Picot^a ; ^b ; Sandrine Ruchaud^c ; Sté ; phane Bach^c ; Blandine Baratte^c ; Michel Sauvain^d ; ^e ; Denis Castillo Pareja^f ; Abraham J. Vaisberg^f ; Patrice Le Pape^b
关键词：Antileishmanial activity ; Imidazo[1 ; 2-a]pyrazines ; Direct arylation ; Casein kinase 1
刊名：European Journal of Medicinal Chemistry
出版年：2015
出版时间：20 October 2015
年：2015
卷：103
期：Complete
页码：381-395
全文大小：1012 K

文摘

•: Imidazo[1,2-a]pyrazines exhibited very promising antileishmanial activities.
•: Proliferation of promastigote and amastigote forms of Leishmania major was inhibited.
•: 20">High selectivity of biological activity against protozoa was highlighted.
•: 25">LmCK1 was detected as one possible molecular target.

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