Protection of non-human primates against rabies with an adenovirus recombinant vaccine

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• 作者：Z.Q. Xiang ; L. Greenberg ; H.C. Ertl ; C.E. Rupprecht
• 关键词：Adenoviral vaccine ; NHP ; Rabies virus ; VNA
• 刊名：Virology
• 出版年：February, 2014
• 年：2014
• 卷：450-451
• 期：Complete
• 页码：243-249
• 全文大小：817 K

文摘

Rabies remains a major neglected global zoonosis. New vaccine strategies are needed for human rabies prophylaxis. A single intramuscular immunization with a moderate dose of an experimental chimpanzee adenovirus (Ad) vector serotype SAd-V24, also termed AdC68, expressing the rabies virus glycoprotein, resulted in sustained titers of rabies virus neutralizing antibodies and protection against a lethal rabies virus challenge infection in a non-human primate model. Taken together, these data demonstrate the safety, immunogenicity, and efficacy of the recombinant Ad-rabies vector for further consideration in human clinical trials.